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, Vahid Tayebi Khorrami Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences , Shiraz 7146864685 , Iran Search for other works by this author on: Oxford Academic Mohammad Javad Raee Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences , Shiraz 7146864685 , Iran Student Research Committee, Shiraz University of Medical Sciences , Shiraz 7146864685 , Iran Correspondence: Shiraz University of Medical Sciences, Shiraz 7146864685, Iran. E-mail: raeem@sums.ac.ir (M.J.R.); abolmaali@sums.ac.ir (S.S.A.) Search for other works by this author on: Oxford Academic Samira Sadat Abolmaali Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences , Shiraz 7146864685 , Iran Department of Pharmaceutical Nanotechnology, School of Pharmacy, Shiraz University of Medical Sciences , Shiraz 7146864685 , Iran Correspondence: Shiraz University of Medical Sciences, Shiraz 7146864685, Iran. E-mail: raeem@sums.ac.ir (M.J.R.); abolmaali@sums.ac.ir (S.S.A.) Search for other works by this author on: Oxford Academic Mozhgan Abedanzadeh Department of Pharmaceutical Nanotechnology, School of Pharmacy, Shiraz University of Medical Sciences , Shiraz 7146864685 , Iran Search for other works by this author on: Oxford Academic Mina Shafiee Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences , Shiraz 7146864685 , Iran Search for other works by this author on: Oxford Academic Ali Mohammad Tamaddon Center for Nanotechnology in Drug Delivery, Shiraz University of Medical Sciences , Shiraz 7146864685 , Iran Department of Pharmaceutical Nanotechnology, School of Pharmacy, Shiraz University of Medical Sciences , Shiraz 7146864685 , Iran Pharmaceutics Department, School of Pharmacy, Shiraz University of Medical Sciences , Shiraz 7146864685 , Iran Search for other works by this author on: Oxford Academic
Journal of Pharmacy and Pharmacology, Volume 76, Issue 8, August 2024, Pages 995–1005, https://doi.org/10.1093/jpp/rgae046
Published:
19 May 2024
Article history
Received:
13 October 2023
Accepted:
17 April 2024
Published:
19 May 2024
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Vahid Tayebi Khorrami, Mohammad Javad Raee, Samira Sadat Abolmaali, Mozhgan Abedanzadeh, Mina Shafiee, Ali Mohammad Tamaddon, Erythrocyte membrane-camouflaged mesoporous silica composite nanoparticles for loading and controlled release of the hepatoprotective agent silibinin: A-synthesis and physicochemical characterization, Journal of Pharmacy and Pharmacology, Volume 76, Issue 8, August 2024, Pages 995–1005, https://doi.org/10.1093/jpp/rgae046
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Abstract
Objectives
Milk thistle has long been used in the treatment of liver and biliary disorders. In the present study, to make a long-acting delivery system for silibinin (SBN, a major active constituent of milk thistle seeds with antioxidant and hepatoprotective function), mesoporous silica composite nanoparticles (NC) were synthesized and coated with RBC membrane.
Methods
A modified Stöber method was used for NC synthesis, which was then characterized using FE-SEM, DLS, TEM, FTIR, and EDAX techniques. A suitable lysis buffer was used to prepare RBC-ghost, and sonication was used to coat SBN-loaded NC (SBN-NC). The RBC-ghost coated SBN-NC (SBN-NC-RBCG) was evaluated by SDS-PAGE, Bradford, TEM, EDAX, and DLS methods. SBN release was then compared for the SBN-NC and SBN-NC-RBCG samples.
Key findings
the RBC membrane proteins were recovered from the coating of SBN-NC-RBCG, and SBN release was sustained over 24 h when compared with the SBN-NC.
Conclusions
Overall, through prolonging circulation in the bloodstream and evading the immune system, the developed system can improve SBN bioavailability in liver inflammation and fibrosis conditions that need further research.
drug delivery, liver fibrosis, mesoporous silica, red blood cell, cell membrane, silibinin
© The Author(s) 2024. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
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